Ontology highlight
ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC2581491 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Sun Weili W Nandi Saikat S Osman Fekret F Ahn Jong Sook JS Jakovleska Jovana J Lorenz Alexander A Whitby Matthew C MC
Molecular cell 20081001 1
The Fanconi anemia (FA) core complex promotes the tolerance/repair of DNA damage at stalled replication forks by catalyzing the monoubiquitination of FANCD2 and FANCI. Intriguingly, the core complex component FANCM also catalyzes branch migration of model Holliday junctions and replication forks in vitro. Here we have characterized the ortholog of FANCM in fission yeast Fml1 in order to understand the physiological significance of this activity. We show that Fml1 has at least two roles in homolo ...[more]