Ontology highlight
ABSTRACT:
SUBMITTER: Fraczek J
PROVIDER: S-EPMC2581573 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Fraczek Jerzy J Kim Tae Whan TW Xiao Hui H Yao Jianhong J Wen Qian Q Li Yali Y Casanova Jean-Laurent JL Pryjma Juliusz J Li Xiaoxia X
The Journal of biological chemistry 20080915 46
Two parallel interleukin-1 (IL-1)-mediated signaling pathways have been uncovered for IL-1R-TLR-mediated NFkappaB activation: TAK1-dependent and MEKK3-dependent pathways, respectively. The TAK1-dependent pathway leads to IKKalpha/beta phosphorylation and IKKbeta activation, resulting in classic NFkappaB activation through IkappaBalpha phosphorylation and degradation. The TAK1-independent MEKK3-dependent pathway involves IKKgamma phosphorylation and IKKalpha activation, resulting in NFkappaB acti ...[more]