Ontology highlight
ABSTRACT:
SUBMITTER: Miyashiro T
PROVIDER: S-EPMC2582279 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Miyashiro Tim T Goulian Mark M
Proceedings of the National Academy of Sciences of the United States of America 20081105 45
We examined the effect of positive autoregulation on the steady-state behavior of the PhoQ/PhoP two-component signaling system in Escherichia coli. We found that autoregulation has no effect on the steady-state output for a large range of input stimulus, which was modulated by varying the concentration of magnesium in the growth medium. We provide an explanation for this finding with a simple model of the PhoQ/PhoP circuit. The model predicts that even when autoregulation is manifest across a ra ...[more]