Antigen-mediated T cell expansion regulated by parallel pathways of death.
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ABSTRACT:
SUBMITTER: Ch'en IL
PROVIDER: S-EPMC2582294 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Antigen-mediated T cell expansion regulated by parallel pathways of death.
Ch'en Irene L IL Beisner Daniel R DR Degterev Alexei A Lynch Candace C Yuan Junying J Hoffmann Alexander A Hedrick Stephen M SM
Proceedings of the National Academy of Sciences of the United States of America 20081103 45
T cells enigmatically require caspase-8, an inducer of apoptosis, for antigen-driven expansion and effective antiviral responses, and yet the pathways responsible for this effect have been elusive. A defect in caspase-8 expression does not affect progression through the cell cycle but causes an abnormally high rate of cell death that is distinct from apoptosis and does not involve a loss of NFkappaB activation. Instead, antigen or mitogen activated Casp8-deficient T cells exhibit an alternative ...[more]
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