Ontology highlight
ABSTRACT:
SUBMITTER: Lusic H
PROVIDER: S-EPMC2582600 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Lusic Hrvoje H Gustilo Estella M EM Vendeix Franck A P FA Kaiser Rob R Delaney Michael O MO Graham William D WD Moye Virginia A VA Cantara William A WA Agris Paul F PF Deiters Alexander A
Nucleic acids research 20081016 20
Human mitochondrial methionine transfer RNA (hmtRNA(Met)(CAU)) has a unique post-transcriptional modification, 5-formylcytidine, at the wobble position-34 (f(5)C(34)). The role of this modification in (hmtRNA(Met)(CAU)) for the decoding of AUA, as well as AUG, in both the peptidyl- and aminoacyl-sites of the ribosome in either chain initiation or chain elongation is still unknown. We report the first synthesis and analyses of the tRNA's anticodon stem and loop domain containing the 5-formylcytid ...[more]