Ontology highlight
ABSTRACT:
SUBMITTER: Wiggin TD
PROVIDER: S-EPMC2582925 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Wiggin Timothy D TD Kretzler Matthias M Pennathur Subramaniam S Sullivan Kelli A KA Brosius Frank C FC Feldman Eva L EL
Endocrinology 20080626 10
Diabetic neuropathy (DN) is a common complication of diabetes. Currently, there is no drug treatment to prevent or slow the development of DN. Rosiglitazone (Rosi) is a potent insulin sensitizer and may also slow the development of DN by a mechanism independent of its effect on hyperglycemia. A two by two design was used to test the effect of Rosi treatment on the development of DN. Streptozotocin-induced diabetic DBA/2J mice were treated with Rosi. DN and oxidative stress were quantified, and g ...[more]