Ontology highlight
ABSTRACT:
SUBMITTER: Arndt JW
PROVIDER: S-EPMC2583140 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Arndt Joseph W JW Yu Wayne W Bi Fay F Stevens Raymond C RC
Biochemistry 20050701 28
The seven serotypes (A-G) of botulinum neurotoxins (BoNTs) block neurotransmitter release through their specific proteolysis of one of the three proteins of the soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (SNARE) complex. BoNTs have stringent substrate specificities that are unique for metalloprotease in that they require exceptionally long substrates (1). To understand the molecular reasons for the unique specificities of the BoNTs, we determined the crystal structure ...[more]