Ontology highlight
ABSTRACT:
SUBMITTER: Ujvari A
PROVIDER: S-EPMC2583294 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Ujvári Andrea A Hsieh Fu-Kai FK Luse Susan W SW Studitsky Vasily M VM Luse Donal S DS
The Journal of biological chemistry 20080923 47
We determined the effect of the N-terminal histone tails on nucleosome traversal by yeast and human RNA polymerase II (pol II). Removal of H2A/H2B tails, H3/H4 tails, or all tails increased complete traversal of the nucleosome by human pol II, although the increase varied considerably depending on the template and on which tails were removed. Human pol II achieved >80% traversal of one nucleosomal template lacking the H2A/H2B tails, but even in those reactions, the transcript elongation rate was ...[more]