Structural insights into fibronectin type III domain-mediated signaling.
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ABSTRACT:
SUBMITTER: Bencharit S
PROVIDER: S-EPMC2583400 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Publications
Structural insights into fibronectin type III domain-mediated signaling.
Bencharit Sompop S Cui Cai Bin CB Siddiqui Adnan A Howard-Williams Escher L EL Sondek John J Zuobi-Hasona Kheir K Aukhil Ikramuddin I
Journal of molecular biology 20061011 2
The alternatively spliced type III extradomain B (EIIIB) of fibronectin (FN) is expressed only during embryogenesis, wound healing and tumorigenesis. The biological function of this domain is unclear. We describe here the first crystal structure of the interface between alternatively spliced EIIIB and its adjacent FN type III domain 8 (FN B-8). The opened CC' loop of EIIIB, and the rotation and tilt of EIIIB allow good access to the FG loop of FN-8, which is normally hindered by the CC' loop of ...[more]
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