Ontology highlight
ABSTRACT:
SUBMITTER: Zahn RC
PROVIDER: S-EPMC2583661 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Zahn Roland C RC Rett Melisa D MD Korioth-Schmitz Birgit B Sun Yue Y Buzby Adam P AP Goldstein Simoy S Brown Charles R CR Byrum Russell A RA Freeman Gordon J GJ Letvin Norman L NL Hirsch Vanessa M VM Schmitz Jörn E JE
Journal of virology 20081001 23
African green monkeys (AGM) do not develop overt signs of disease following simian immunodeficiency virus (SIV) infection. While it is still unknown how natural hosts like AGM can cope with this lentivirus infection, a large number of investigations have shown that CD8(+) T-cell responses are critical for the containment of AIDS viruses in humans and Asian nonhuman primates. Here we have compared the phenotypes of T-cell subsets and magnitudes of SIV-specific CD8(+) T-cell responses in vervet AG ...[more]