Ontology highlight
ABSTRACT:
SUBMITTER: Jessop L
PROVIDER: S-EPMC2584117 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Jessop Lea L Lichten Michael M
Molecular cell 20080801 3
Budding yeast lacking the Sgs1 helicase and the Mus81/Mms4 endonuclease are inviable, and indirect studies implicate homologous recombination gone awry as the cause of death. We show that mutants lacking both enzymes have profound defects in meiotic recombination intermediate metabolism and crossover (CO) formation. Recombination intermediates (joint molecules, JMs) accumulate in these cells, many with structures that are infrequent in wild-type cells. These JMs persist, preventing nuclear divis ...[more]