PH controlled release of chromone from chromone-Fe3O4 nanoparticles.
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ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC2584374 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
pH controlled release of chromone from chromone-Fe3O4 nanoparticles.
Wang Baodui B Xu Chenjie C Xie Jin J Yang Zhengyin Z Sun Shouheng S
Journal of the American Chemical Society 20081008 44
We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system fo ...[more]
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