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Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice.

ABSTRACT: At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.

SUBMITTER: Pantaleo MA

PROVIDER: S-EPMC2584956 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice.

Pantaleo M A MA Astolfi A A Nannini M M Paterini P P Piazzi G G Ercolani G G Brandi G G Martinelli G G Pession A A Pinna A D AD Biasco G G

British journal of cancer 20080930 10

At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways. ...[more]

PMID: 18827815

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