Maternal exposure to folic acid antagonists and placenta-mediated adverse pregnancy outcomes.

ABSTRACT:

Background

In previous studies, maternal exposure to folic acid antagonists was associated with increased risks of neural tube defects, cardiovascular defects, oral clefts and urinary tract defects. The objective of the current study was to assess the possible effects of using folic acid antagonists in pregnancy on placenta-mediated adverse outcomes of pregnancy.

Methods

We used data from an administrative database to retrospectively compare the occurrence of placenta-mediated adverse pregnancy outcomes between pregnant women exposed to folic acid antagonists and women without exposure to these agents.

Results

We included in the analysis a total of 14 982 women who had been exposed to folic acid antagonists and 59 825 women who had not been exposed. Sulfamethoxazole-t

SUBMITTER: Wen SW 

PROVIDER: S-EPMC2585135 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature