Ontology highlight
ABSTRACT:
SUBMITTER: Fallon MJ
PROVIDER: S-EPMC2585369 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Fallon Michael J MJ MacDonald Michael J MJ
Metabolism: clinical and experimental 20080801 8
The presence of Fe(II) alpha-ketoglutarate hydroxylases in rat and human pancreatic islets and INS-1 832/13 cells was demonstrated with the reverse transcriptase polymerase chain reaction (PHD1, 2, and 3; lysyl hydroxylases 1, 2, and 3; and phytanoyl-coenzyme A hydroxylase were seen) and/or immunoblotting (high levels of proline hydroxylase P4Halpha1, PHD2, and PHD4 and low levels of PHD2 and PHD3 in human islets, and high levels of PHD2 in rat islets and INS-1 cells were seen). Prolyl hydroxyla ...[more]