Ontology highlight
ABSTRACT:
SUBMITTER: Seitsonen SP
PROVIDER: S-EPMC2585793 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Seitsonen Sanna P SP Onkamo Päivi P Peng Gang G Xiong Momiao M Tommila Petri V PV Ranta Päivi H PH Holopainen Juha M JM Moilanen Jukka A JA Palosaari Tapani T Kaarniranta Kai K Meri Seppo S Immonen Ilkka R IR Järvelä Irma E IE
PloS one 20081202 12
<h4>Background</h4>Variants in the complement cascade genes and the LOC387715/HTRA1, have been widely reported to associate with age-related macular degeneration (AMD), the most common cause of visual impairment in industrialized countries.<h4>Methods/principal findings</h4>We investigated the association between the LOC387715 A69S and complement component C3 R102G risk alleles in the Finnish case-control material and found a significant association with both variants (OR 2.98, p = 3.75 x 10(-9) ...[more]