Virus capsid expansion driven by the capture of mobile surface loops.
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ABSTRACT:
SUBMITTER: Lee KK
PROVIDER: S-EPMC2586091 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
Virus capsid expansion driven by the capture of mobile surface loops.
Lee Kelly K KK Gan Lu L Tsuruta Hiro H Moyer Crystal C Conway James F JF Duda Robert L RL Hendrix Roger W RW Steven Alasdair C AC Johnson John E JE
Structure (London, England : 1993) 20081001 10
The capsids of tailed-DNA bacteriophages first assemble as procapsids, which mature by converting into a new form that is strong enough to contain a densely packed viral chromosome. We demonstrate that the intersubunit crosslinking that occurs during maturation of HK97 capsids actually promotes the structural transformation. Small-angle X-ray scattering and crosslinking assays reveal that a shift in the crosslink pattern accompanies conversion of a semimature particle, Expansion Intermediate-I/I ...[more]
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