Ontology highlight
ABSTRACT:
SUBMITTER: Kim AY
PROVIDER: S-EPMC2586271 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Kim Alexander Y AY Bommeljé Claire C CC Lee Benjamin E BE Yonekawa Yoshihiro Y Choi Lydia L Morris Luc G LG Huang Guochang G Kaufman Andrew A Ryan Russel J H RJ Hao Bing B Ramanathan Y Y Singh Bhuvanesh B
The Journal of biological chemistry 20080930 48
Covalent modification of cullins by the ubiquitin-like protein NEDD8 (neddylation) regulates protein ubiquitination by promoting the assembly of cullin-RING ligase E3 complexes. Like ubiquitination, neddylation results from an enzymatic cascade involving the sequential activity of a dedicated E1 (APPBP1/Uba3), E2 (Ubc12), and an ill-defined E3. We show that SCCRO (also known as DCUN1D1) binds to the components of the neddylation pathway (Cullin-ROC1, Ubc12, and CAND1) and augments but is not req ...[more]