A spatial toggle switch drives boundary formation in development.
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ABSTRACT:
SUBMITTER: Canela-Xandri O
PROVIDER: S-EPMC2586583 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
A spatial toggle switch drives boundary formation in development.
Canela-Xandri Oriol O Sagués Francesc F Reigada Ramón R Buceta Javier J
Biophysical journal 20080912 11
Herein we introduce a multicellular network motif that performs as a spatial toggle switch and explains how boundary formation can be faithfully accomplished in developmental processes. Importantly, we show that expression and activity patterns of proteins must be simultaneously characterized for a proper understanding and description of the underlying mechanism. Our in silico experiments, in agreement with in vivo results, evaluate different genetic backgrounds and shed light on the dynamics of ...[more]
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