Ontology highlight
ABSTRACT:
SUBMITTER: Folco HD
PROVIDER: S-EPMC2586718 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Folco Hernan Diego HD Pidoux Alison L AL Urano Takeshi T Allshire Robin C RC
Science (New York, N.Y.) 20080101 5859
Heterochromatin is defined by distinct posttranslational modifications on histones, such as methylation of histone H3 at lysine 9 (H3K9), which allows heterochromatin protein 1 (HP1)-related chromodomain proteins to bind. Heterochromatin is frequently found near CENP-A chromatin, which is the key determinant of kinetochore assembly. We have discovered that the RNA interference (RNAi)-directed heterochromatin flanking the central kinetochore domain at fission yeast centromeres is required to prom ...[more]