Ontology highlight
ABSTRACT:
SUBMITTER: Quarles LD
PROVIDER: S-EPMC2586800 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20081201 12
Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and other organs to adjust phosphate balance and bone mineralization in response to changing physiological r ...[more]