Ontology highlight
ABSTRACT:
SUBMITTER: Byrne GW
PROVIDER: S-EPMC2586876 | biostudies-literature | 2008 Jul-Aug
REPOSITORIES: biostudies-literature
Byrne Guerard W GW Stalboerger Paul G PG Davila Eduardo E Heppelmann Carrie J CJ Gazi Mozammel H MH McGregor Hugh C J HC LaBreche Peter T PT Davies William R WR Rao Vinay P VP Oi Keiji K Tazelaar Henry D HD Logan John S JS McGregor Christopher G A CG
Xenotransplantation 20080701 4
<h4>Background</h4>Experience with non-antigenic galactose alpha1,3 galactose (alphaGal) polymers and development of alphaGal deficient pigs has reduced or eliminated the significance of this antigen in xenograft rejection. Despite these advances, delayed xenograft rejection (DXR) continues to occur most likely due to antibody responses to non-Gal endothelial cell (EC) antigens.<h4>Methods</h4>To gauge the diversity of the non-Gal antibody response we used antibody derived from CD46 transgenic h ...[more]