Ontology highlight
ABSTRACT:
SUBMITTER: Collins RE
PROVIDER: S-EPMC2586904 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Collins Robert E RE Northrop Jeffrey P JP Horton John R JR Lee David Y DY Zhang Xing X Stallcup Michael R MR Cheng Xiaodong X
Nature structural & molecular biology 20080210 3
Histone modifications have important roles in transcriptional control, mitosis and heterochromatin formation. G9a and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). Here we demonstrate that the ankyrin repeat domains of G9a and GLP bind with strong preference to N-terminal H3 peptides containing mono- or dimethyl K9. X-ray crystallography revealed the basis for recognition of the methylated lys ...[more]