Ontology highlight
ABSTRACT:
SUBMITTER: Suh JM
PROVIDER: S-EPMC2587167 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Suh Jae Myoung JM Zeve Daniel D McKay Renee R Seo Jin J Salo Zack Z Li Robert R Wang Michael M Graff Jonathan M JM
Cell metabolism 20070901 3
Adipose (Adp) is an evolutionarily conserved gene isolated from naturally occurring obese flies homozygous for an adp mutation. Here we show that the anti-obesity function of Adp (worm Y73E7A.9, fly adp, and murine Wdtc1) is conserved from worms to mammals. Further, Adp appears to inhibit fat formation in a dosage-sensitive manner. Adp heterozygous flies and Adp heterozygous mutant mice are obese and insulin resistant, as are mice that express a dominant negative form of Adp in fat cells. Conver ...[more]