Ontology highlight
ABSTRACT:
SUBMITTER: Sablin EP
PROVIDER: S-EPMC2587556 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Sablin Elena P EP Woods April A Krylova Irina N IN Hwang Peter P Ingraham Holly A HA Fletterick Robert J RJ
Proceedings of the National Academy of Sciences of the United States of America 20081117 47
The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate ...[more]