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Nanoparticle-induced surface reconstruction of phospholipid membranes.

ABSTRACT: The nonspecific adsorption of charged nanoparticles onto single-component phospholipid bilayers bearing phosphocholine headgroups is shown, from fluorescence and calorimetry experiments, to cause surface reconstruction at the points where nanoparticles adsorb. Nanoparticles of negative charge induce local gelation in otherwise fluid bilayers; nanoparticles of positive charge induce otherwise gelled membranes to fluidize locally. Through this mechanism, the phase state deviates from the nominal phase transition temperature by tens of degrees. This work generalizes the notions of environmentally induced surface reconstruction, prominent in metals and semiconductors. Bearing in mind that chemical composition in these single-component lipid bilayers is the same everywhere, this offers a mechanism to generate patchy functional properties in phospholipid membranes.

SUBMITTER: Wang B

PROVIDER: S-EPMC2587577 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Nanoparticle-induced surface reconstruction of phospholipid membranes.

Wang Bo B Zhang Liangfang L Bae Sung Chul SC Granick Steve S

Proceedings of the National Academy of Sciences of the United States of America 20081114 47

The nonspecific adsorption of charged nanoparticles onto single-component phospholipid bilayers bearing phosphocholine headgroups is shown, from fluorescence and calorimetry experiments, to cause surface reconstruction at the points where nanoparticles adsorb. Nanoparticles of negative charge induce local gelation in otherwise fluid bilayers; nanoparticles of positive charge induce otherwise gelled membranes to fluidize locally. Through this mechanism, the phase state deviates from the nominal p ...[more]

PMID: 19011086

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