Ontology highlight
ABSTRACT:
SUBMITTER: Bajpai S
PROVIDER: S-EPMC2587611 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Bajpai Saumendra S Correia Joana J Feng Yunfeng Y Figueiredo Joana J Sun Sean X SX Longmore Gregory D GD Suriano Gianpaolo G Wirtz Denis D
Proceedings of the National Academy of Sciences of the United States of America 20081118 47
alpha-Catenin is essential in cadherin-mediated epithelium development and maintenance of tissues and in cancer progression and metastasis. However, recent studies question the conventional wisdom that alpha-catenin directly bridges the cadherin adhesion complex to the actin cytoskeleton. Therefore, whether alpha-catenin plays a direct role in cadherin-dependent cell adhesion is unknown. Here, single-molecule force spectroscopy measurements in cells depleted of alpha-catenin or expressing the he ...[more]