Unknown

Dataset Information

0

Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai.

ABSTRACT: The marine mollusk Aplysia is a useful model organism for studying the cellular bases of behavior and plasticity. However, molecular studies of Aplysia have been limited by the lack of genomic information. Recently, a large scale characterization of neuronal transcripts was performed in A. californica. Here, we report the analysis of a parallel set of neuronal transcripts from a closely related species A. kurodai found in the northwestern Pacific. We collected 4,859 nonredundant sequences from the nervous system tissue of A. kurodai. By performing microarray and real-time PCR analyses, we found that ApC/EBP, matrilin, antistasin, and eIF3e clones were significantly up-regulated and a BAT1 homologous clone was significantly down-regulated by 5-HT treatment. Among these, we further demonstrated that the Ap-eIF3e plays a key role in 5-HT-induced long-term facilitation (LTF) as a positive regulator.

SUBMITTER: Lee YS 

PROVIDER: S-EPMC2587617 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai.

Lee Yong-Seok YS   Choi Sun-Lim SL   Kim Tae-Hyung TH   Lee Jin-A JA   Kim Hyong Kyu HK   Kim Hyoung H   Jang Deok-Jin DJ   Lee Jennifer J JJ   Lee Sunghoon S   Sin Gwang Sik GS   Kim Chang-Bae CB   Suzuki Yutaka Y   Sugano Sumio S   Kubo Tai T   Moroz Leonid L LL   Kandel Eric R ER   Bhak Jong J   Kaang Bong-Kiun BK  

Proceedings of the National Academy of Sciences of the United States of America 20081118 47

The marine mollusk Aplysia is a useful model organism for studying the cellular bases of behavior and plasticity. However, molecular studies of Aplysia have been limited by the lack of genomic information. Recently, a large scale characterization of neuronal transcripts was performed in A. californica. Here, we report the analysis of a parallel set of neuronal transcripts from a closely related species A. kurodai found in the northwestern Pacific. We collected 4,859 nonredundant sequences from t  ...[more]

Similar Datasets

Unknown Differential evolutionary rates of neuronal transcriptome in Aplysia kurodai and Aplysia californica as a tool for gene mining.
| S-EPMC8212809 | biostudies-literature
Unknown A presynaptic role for FMRP during protein synthesis-dependent long-term plasticity in Aplysia.
| S-EPMC3023967 | biostudies-literature
Unknown Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons.
| S-EPMC8298407 | biostudies-literature
Unknown Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia.
| S-EPMC4108396 | biostudies-literature
Unknown Antiproliferative and Antimicrobial Potentials of a Lectin from Aplysia kurodai (Sea Hare) Eggs.
| S-EPMC8306185 | biostudies-literature
Unknown Characterization of a GHF45 cellulase, AkEG21, from the common sea hare Aplysia kurodai.
| S-EPMC4123733 | biostudies-literature
Unknown Postsynaptic regulation of long-term facilitation in Aplysia.
| S-EPMC2711037 | biostudies-literature
Unknown Transcriptional analysis of a whole-body form of long-term habituation in Aplysia californica.
| S-EPMC4274328 | biostudies-literature
Unknown AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia.
| S-EPMC3458389 | biostudies-literature
Unknown Structure of β-1,4-mannanase from the common sea hare Aplysia kurodai at 1.05 A resolution.
| S-EPMC3497972 | biostudies-literature