Common patterns of bcl-2 family gene expression in two traumatic brain injury models.
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ABSTRACT:
SUBMITTER: Strauss KI
PROVIDER: S-EPMC2590760 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
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Common patterns of bcl-2 family gene expression in two traumatic brain injury models.
Strauss Kenneth I KI Narayan Raj K RK Raghupathi Ramesh R
Neurotoxicity research 20040101 4
Cell death/survival following traumatic brain injury (TBI) may be a result of alterations in the intracellular ratio of death and survival factors. Bcl-2 family genes mediate both cell survival and the initiation of cell death. Using lysate RNase protection assays, mRNA expression of the anti-cell death genes Bcl-2 and Bcl-xL, and the pro-cell death gene Bax, was evaluated following experimental brain injuries in adult male Sprague-Dawley rats. Both the lateral fluid-percussion (LFP) and the lat ...[more]
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