Ontology highlight
ABSTRACT:
SUBMITTER: Li MD
PROVIDER: S-EPMC2592606 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Li Ming D MD Lou Xiang-Yang XY Chen Guobo G Ma Jennie Z JZ Elston Robert C RC
Biological psychiatry 20080604 11
<h4>Background</h4>Epidemiological data indicate that nicotine dependence (ND) are influenced by genes, environmental factors, and their interactions. Although it has been documented from molecular experiments that brain-derived neurotrophic factor (BDNF) exerts its functions via neurotrophic tyrosine kinase receptor 2 (NTRK2) and both alpha 4 (CHRNA4) and beta 2 (CHRNB2) subunits are required to form functional alpha 4 beta 2-containing nicotinic receptors (nAChRs), no study is reported demonst ...[more]