Ontology highlight
ABSTRACT:
SUBMITTER: Tominaga H
PROVIDER: S-EPMC2592674 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Tominaga Hiroyuki H Maeda Shingo S Hayashi Makoto M Takeda Shu S Akira Shizuo S Komiya Setsuro S Nakamura Takashi T Akiyama Haruhiko H Imamura Takeshi T
Molecular biology of the cell 20081008 12
Although CCAAT/enhancer-binding protein beta (C/EBPbeta) is involved in osteocalcin gene expression in osteoblast in vitro, the physiological importance of and molecular mechanisms governing C/EBPbeta in bone formation remain to be elucidated. In particular, it remains unclear whether C/EBPbeta acts as a homodimer or a heterodimer with other proteins during osteoblast differentiation. Here, deletion of the C/EBPbeta gene from mice resulted in delayed bone formation with concurrent suppression of ...[more]