Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes.
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ABSTRACT: Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(-1) of insulin with no significant background secretion.
SUBMITTER: Duan F
PROVIDER: S-EPMC2592943 | biostudies-literature |
REPOSITORIES: biostudies-literature
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