Ontology highlight
ABSTRACT:
SUBMITTER: Zehetner J
PROVIDER: S-EPMC2593613 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Zehetner Jens J Danzer Carsten C Collins Stephan S Eckhardt Katrin K Gerber Philipp A PA Ballschmieter Pia P Galvanovskis Juris J Shimomura Kenju K Ashcroft Frances M FM Thorens Bernard B Rorsman Patrik P Krek Wilhelm W
Genes & development 20081101 22
Insulin secretion from pancreatic beta cells is stimulated by glucose metabolism. However, the relative importance of metabolizing glucose via mitochondrial oxidative phosphorylation versus glycolysis for insulin secretion remains unclear. von Hippel-Lindau (VHL) tumor suppressor protein, pVHL, negatively regulates hypoxia-inducible factor HIF1alpha, a transcription factor implicated in promoting a glycolytic form of metabolism. Here we report a central role for the pVHL-HIF1alpha pathway in the ...[more]