Ontology highlight
ABSTRACT:
SUBMITTER: Dix MM
PROVIDER: S-EPMC2597167 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Dix Melissa M MM Simon Gabriel M GM Cravatt Benjamin F BF
Cell 20080801 4
Proteolysis is a key regulatory process that promotes the (in)activation, translocation, and/or degradation of proteins. As such, there is considerable interest in methods to comprehensively characterize proteolytic pathways in biological systems. Here, we describe a robust and versatile proteomic platform that enables direct visualization of the topography and magnitude of proteolytic events on a global scale. We use this method to generate a proteome-wide map of proteolytic events induced by t ...[more]