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Large ventral lateral neurons modulate arousal and sleep in Drosophila.

ABSTRACT: Large ventral lateral clock neurons (lLNvs) exhibit higher daytime-light-driven spontaneous action-potential firing rates in Drosophila, coinciding with wakefulness and locomotor-activity behavior. To determine whether the lLNvs are involved in arousal and sleep/wake behavior, we examined the effects of altered electrical excitation of the LNvs.LNv-hyperexcited flies reverse the normal day-night firing pattern, showing higher lLNv firing rates at night and pigment-dispersing-factor-mediated enhancement of nocturnal locomotor-activity behavior and reduced quantity and quality of sleep. lLNv hyperexcitation impairs sensory arousal, as shown by physiological and behavioral assays. lLNv-hyperexcited flies lacking sLNvs exhibit robust hyperexcitation-induced increases in nocturnal behavior, suggesting that the sLNvs are not essential for mediation of arousal.Light-activated lLNvs modulate behavioral arousal and sleep in Drosophila.

SUBMITTER: Sheeba V

PROVIDER: S-EPMC2597195 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Large ventral lateral neurons modulate arousal and sleep in Drosophila.

Sheeba Vasu V Fogle Keri J KJ Kaneko Maki M Rashid Saima S Chou Yu-Ting YT Sharma Vijay K VK Holmes Todd C TC

Current biology : CB 20080904 20

<h4>Background</h4>Large ventral lateral clock neurons (lLNvs) exhibit higher daytime-light-driven spontaneous action-potential firing rates in Drosophila, coinciding with wakefulness and locomotor-activity behavior. To determine whether the lLNvs are involved in arousal and sleep/wake behavior, we examined the effects of altered electrical excitation of the LNvs.<h4>Results</h4>LNv-hyperexcited flies reverse the normal day-night firing pattern, showing higher lLNv firing rates at night and pigm ...[more]

PMID: 18771923

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