Ontology highlight
ABSTRACT:
SUBMITTER: Gonzales MJ
PROVIDER: S-EPMC2597357 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Gonzales M J MJ Machekano R N RN Shafer R W RW
The Journal of infectious diseases 20010910 8
Phylogenetic analysis of the reverse transcriptase (RT) and protease of 117 published complete human immunodeficiency virus (HIV) type 1 genome sequences demonstrated that these genes cluster into distinct subtypes. There was a slightly higher proportion of informative sites in the RT (40.4%) than in the protease (34.8%; P= .03). Although most variation between subtypes was due to synonymous nucleotide substitutions, several subtype-specific amino acid patterns were observed. In the protease, th ...[more]