Ontology highlight
ABSTRACT:
SUBMITTER: Shi W
PROVIDER: S-EPMC2597519 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Shi Weiguo W Qi Zhi Z Pan Chungen C Xue Na N Debnath Asim K AK Qie Jiankun J Jiang Shibo S Liu Keliang K
Biochemical and biophysical research communications 20080803 4
The peptidic anti-HIV drug T20 (Fuzeon) and its analog C34 share a common heptad repeat (HR) sequence, but they have different functional domains, i.e., pocket- and lipid-binding domains (PBD and LBD, respectively). We hypothesize that novel anti-HIV peptides may be designed by using artificial sequences containing multiple copies of HR motifs plus zero, one or two functional domains. Surprisingly, we found that the peptides containing only the non-natural HR sequences could significantly inhibi ...[more]