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Phosphonic acid monolayers for binding of bioactive molecules to titanium surfaces.


ABSTRACT: Two different phosphonic acid monolayer films for immobilization of bioactive molecules such as the protein BMP-2 on titanium surfaces have been prepared. Monolayers of (11-hydroxyundecyl)phosphonic acid and (12-carboxydodecyl)phosphonic acid molecules were produced by a simple dipping process (the T-BAG method). The terminal functional groups on these monolayers were activated (carbonyldiimidazole for hydroxyl groups and N-hydroxysuccinimide for carboxyl groups) to bind amine-containing molecules. The reactivity of the surfaces was investigated using trifluoroethylamine hydrochloride and BMP-2. Each step of the surface modification procedure was characterized by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry.

SUBMITTER: Adden N 

PROVIDER: S-EPMC2597787 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature

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Phosphonic acid monolayers for binding of bioactive molecules to titanium surfaces.

Adden Nina N   Gamble Lara J LJ   Castner David G DG   Hoffmann Andrea A   Gross Gerhard G   Menzel Henning H  

Langmuir : the ACS journal of surfaces and colloids 20060901 19


Two different phosphonic acid monolayer films for immobilization of bioactive molecules such as the protein BMP-2 on titanium surfaces have been prepared. Monolayers of (11-hydroxyundecyl)phosphonic acid and (12-carboxydodecyl)phosphonic acid molecules were produced by a simple dipping process (the T-BAG method). The terminal functional groups on these monolayers were activated (carbonyldiimidazole for hydroxyl groups and N-hydroxysuccinimide for carboxyl groups) to bind amine-containing molecul  ...[more]

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