Ontology highlight
ABSTRACT:
SUBMITTER: Virtanen IM
PROVIDER: S-EPMC2598035 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Virtanen I M IM Song Y Q YQ Cheung K M C KM Ala-Kokko L L Karppinen J J Ho D W H DW Luk K D K KD Yip S P SP Leong J C Y JC Cheah K S E KS Sham P P Chan D D
Journal of medical genetics 20070112 4
<h4>Background</h4>Lumbar disc disease (LDD) is one of the leading causes of disability in the working-age population. A functional single-nucleotide polymorphism (SNP), +1184T-->C, in exon 8 of the cartilage intermediate layer protein gene (CILP) was recently identified as a risk factor for LDD in the Japanese population (odds ratio (OR) 1.61, 95% CI 1.31 to 1.98), with implications for impaired transforming growth factorbeta1 signalling.<h4>Aim</h4>To validate this finding in two different eth ...[more]