Ontology highlight
ABSTRACT:
SUBMITTER: Mohazab AR
PROVIDER: S-EPMC2599856 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Mohazab Ali R AR Plotkin Steven S SS
Biophysical journal 20080926 12
The minimal folding pathway or trajectory for a biopolymer can be defined as the transformation that minimizes the total distance traveled between a folded and an unfolded structure. This involves generalizing the usual Euclidean distance from points to one-dimensional objects such as a polymer. We apply this distance here to find minimal folding pathways for several candidate protein fragments, including the helix, the beta-hairpin, and a nonplanar structure where chain noncrossing is important ...[more]