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High genetic diversity of measles virus, World Health Organization European Region, 2005-2006.

ABSTRACT: During 2005-2006, nine measles virus (MV) genotypes were identified throughout the World Health Organization European Region. All major epidemics were associated with genotypes D4, D6, and B3. Other genotypes (B2, D5, D8, D9, G2, and H1) were only found in limited numbers of cases after importation from other continents. The genetic diversity of endemic D6 strains was low; genotypes C2 and D7, circulating in Europe until recent years, were no longer identified. The transmission chains of several indigenous MV strains may thus have been interrupted by enhanced vaccination. However, multiple importations from Africa and Asia and virus introduction into highly mobile and unvaccinated communities caused a massive spread of D4 and B3 strains throughout much of the region. Thus, despite the reduction of endemic MV circulation, importation of MV from other continents caused prolonged circulation and large outbreaks after their introduction into unvaccinated and highly mobile communities.

SUBMITTER: Kremer JR 

PROVIDER: S-EPMC2600148 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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High genetic diversity of measles virus, World Health Organization European Region, 2005-2006.

Kremer Jacques R JR   Brown Kevin E KE   Jin Li L   Santibanez Sabine S   Shulga Sergey V SV   Aboudy Yair Y   Demchyshyna Irina V IV   Djemileva Sultana S   Echevarria Juan E JE   Featherstone David F DF   Hukic Mirsada M   Johansen Kari K   Litwinska Bogumila B   Lopareva Elena E   Lupulescu Emilia E   Mentis Andreas A   Mihneva Zefira Z   Mosquera Maria M MM   Muscat Mark M   Naumova M A MA   Nedeljkovic Jasminka J   Nekrasova Ljubov S LS   Magurano Fabio F   Fortuna Claudia C   de Andrade Helena Rebelo HR   Richard Jean-Luc JL   Robo Alma A   Rota Paul A PA   Samoilovich Elena O EO   Sarv Inna I   Semeiko Galina V GV   Shugayev Nazim N   Utegenova Elmira S ES   van Binnendijk Rob R   Vinner Lasse L   Waku-Kouomou Diane D   Wild T Fabian TF   Brown David W G DW   Mankertz Annette A   Muller Claude P CP   Mulders Mick N MN  

Emerging infectious diseases 20080101 1

During 2005-2006, nine measles virus (MV) genotypes were identified throughout the World Health Organization European Region. All major epidemics were associated with genotypes D4, D6, and B3. Other genotypes (B2, D5, D8, D9, G2, and H1) were only found in limited numbers of cases after importation from other continents. The genetic diversity of endemic D6 strains was low; genotypes C2 and D7, circulating in Europe until recent years, were no longer identified. The transmission chains of several  ...[more]