Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model.
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ABSTRACT:
SUBMITTER: Wakita H
PROVIDER: S-EPMC2601631 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
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Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model.
Wakita Hideaki H Ruetzler Christl C Illoh Kachikwu O KO Chen Yong Y Takanohashi Asako A Spatz Maria M Hallenbeck John M JM
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070718 2
Vascular cognitive impairment (VCI) is the second most prevalent type of dementia in the world. The white matter damage that characterizes the common subcortical ischemic form of VCI can be modeled by ligating both common carotid arteries in the Wistar rat to induce protracted cerebral hypoperfusion. In this model, we find that repetitive intranasal administration of recombinant E-selectin to induce mucosal tolerance and to target immunomodulation to activating blood vessels potently suppresses ...[more]
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