Ontology highlight
ABSTRACT:
SUBMITTER: Bolger TA
PROVIDER: S-EPMC2601711 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Bolger Timothy A TA Folkmann Andrew W AW Tran Elizabeth J EJ Wente Susan R SR
Cell 20080801 4
Gene expression requires proper messenger RNA (mRNA) export and translation. However, the functional links between these consecutive steps have not been fully defined. Gle1 is an essential, conserved mRNA export factor whose export function is dependent on the small molecule inositol hexakisphosphate (IP(6)). Here, we show that both Gle1 and IP(6) are required for efficient translation termination in Saccharomyces cerevisiae and that Gle1 interacts with termination factors. In addition, Gle1 has ...[more]