Ontology highlight
ABSTRACT:
SUBMITTER: Vilfan ID
PROVIDER: S-EPMC2602768 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Vilfan Igor D ID Candelli Andrea A Hage Susanne S Aalto Antti P AP Poranen Minna M MM Bamford Dennis H DH Dekker Nynke H NH
Nucleic acids research 20081105 22
RNA-dependent RNA polymerases (RdRP) form an important class of enzymes that is responsible for genome replication and transcription in RNA viruses and involved in the regulation of RNA interference in plants and fungi. The RdRP kinetics have been extensively studied, but pausing, an important regulatory mechanism for RNA polymerases that has also been implicated in RNA recombination, has not been considered. Here, we report that RdRP experience a dramatic, long-lived decrease in its elongation ...[more]