Ontology highlight
ABSTRACT:
SUBMITTER: Gagne JP
PROVIDER: S-EPMC2602769 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Gagné Jean-Philippe JP Isabelle Maxim M Lo Ken Sin KS Bourassa Sylvie S Hendzel Michael J MJ Dawson Valina L VL Dawson Ted M TM Poirier Guy G GG
Nucleic acids research 20081103 22
Poly(ADP-ribose) (pADPr) is a polymer assembled from the enzymatic polymerization of the ADP-ribosyl moiety of NAD by poly(ADP-ribose) polymerases (PARPs). The dynamic turnover of pADPr within the cell is essential for a number of cellular processes including progression through the cell cycle, DNA repair and the maintenance of genomic integrity, and apoptosis. In spite of the considerable advances in the knowledge of the physiological conditions modulated by poly(ADP-ribosyl)ation reactions, an ...[more]