Ontology highlight
ABSTRACT:
SUBMITTER: Roestenberg M
PROVIDER: S-EPMC2602972 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Roestenberg Meta M Remarque Ed E de Jonge Erik E Hermsen Rob R Blythman Hildur H Leroy Odile O Imoukhuede Egeruan E Jepsen Soren S Ofori-Anyinam Opokua O Faber Bart B Kocken Clemens H M CH Arnold Miranda M Walraven Vanessa V Teelen Karina K Roeffen Will W de Mast Quirijn Q Ballou W Ripley WR Cohen Joe J Dubois Marie Claude MC Ascarateil Stéphane S van der Ven Andre A Thomas Alan A Sauerwein Robert R
PloS one 20081218 12
<h4>Background</h4>Plasmodium falciparum Apical Membrane Antigen 1 (PfAMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies.<h4>Methodology/principal findings</h4>We assessed the safety and immunogenicity of recombinant PfAMA1 in a dose-escalating, phase Ia trial. PfAMA1 FVO strain, produced in Pichia pastoris, was reconstituted at 10 microg and 50 microg doses with three diffe ...[more]