Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava K
PROVIDER: S-EPMC2603442 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Cell host & microbe 20080801 2
Cerebral malaria (CM) is a major complication of Plasmodium falciparum infection in children. The pathogenesis of CM involves vascular inflammation, immune stimulation, and obstruction of cerebral capillaries. Platelets have a prominent role in both immune responses and vascular obstruction. We now demonstrate that the platelet-derived chemokine, platelet factor 4 (PF4)/CXCL4, promotes the development of experimental cerebral malaria (ECM). Plasmodium-infected red blood cells (RBCs) activated pl ...[more]