Unknown

Dataset Information

0

Platelet factor 4 mediates inflammation in experimental cerebral malaria.


ABSTRACT: Cerebral malaria (CM) is a major complication of Plasmodium falciparum infection in children. The pathogenesis of CM involves vascular inflammation, immune stimulation, and obstruction of cerebral capillaries. Platelets have a prominent role in both immune responses and vascular obstruction. We now demonstrate that the platelet-derived chemokine, platelet factor 4 (PF4)/CXCL4, promotes the development of experimental cerebral malaria (ECM). Plasmodium-infected red blood cells (RBCs) activated platelets independently of vascular effects, resulting in increased plasma PF4. PF4 or chemokine receptor CXCR3 null mice had less severe ECM, including decreased T cell recruitment to the brain, and platelet depletion or aspirin treatment reduced the development of ECM. We conclude that Plasmodium-infected RBCs can directly activate platelets, and platelet-derived PF4 then contributes to immune activation and T cell trafficking as part of the pathogenesis of ECM.

SUBMITTER: Srivastava K 

PROVIDER: S-EPMC2603442 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications


Cerebral malaria (CM) is a major complication of Plasmodium falciparum infection in children. The pathogenesis of CM involves vascular inflammation, immune stimulation, and obstruction of cerebral capillaries. Platelets have a prominent role in both immune responses and vascular obstruction. We now demonstrate that the platelet-derived chemokine, platelet factor 4 (PF4)/CXCL4, promotes the development of experimental cerebral malaria (ECM). Plasmodium-infected red blood cells (RBCs) activated pl  ...[more]

Similar Datasets

| S-EPMC2862712 | biostudies-literature
| S-EPMC3633624 | biostudies-literature
2019-02-19 | E-MTAB-5513 | biostudies-arrayexpress
2016-12-19 | GSE86082 | GEO
| S-EPMC6205430 | biostudies-literature
| S-EPMC2949229 | biostudies-literature
| S-EPMC4816336 | biostudies-literature
| S-EPMC5784021 | biostudies-literature
2015-01-16 | E-GEOD-65036 | biostudies-arrayexpress
| S-EPMC2837133 | biostudies-literature