Ontology highlight
ABSTRACT:
SUBMITTER: Swenson-Fields KI
PROVIDER: S-EPMC2603627 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Swenson-Fields Katherine I KI Sandquist Joshua C JC Rossol-Allison Jessica J Blat Irene C IC Wennerberg Krister K Burridge Keith K Means Anthony R AR
Molecular cell 20081001 1
Mixed lineage kinase 3 (MLK3) is a MAP3K that activates the JNK-dependent MAPK pathways. Here, we show that MLK3 is required for cell migration in a manner independent of its role as a MAP3K or MLK3 kinase activity. Rather, MLK3 functions in a regulated way to limit levels of the activated GTPase Rho by binding to the Rho activator, p63RhoGEF/GEFT, which, in turn, prevents its activation by Galphaq. These findings demonstrate a scaffolding role for MLK3 in controlling the extent of Rho activatio ...[more]