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Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein.

ABSTRACT: Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK and its pathways. Here we summarize structural features of MARK and cellular pathways of regulation.

SUBMITTER: Timm T 

PROVIDER: S-EPMC2604893 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein.

Timm Thomas T   Marx Alexander A   Panneerselvam Saravanan S   Mandelkow Eckhard E   Mandelkow Eva-Maria EM  

BMC neuroscience 20081203

Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK and its pathways. Here we summarize structural features of MARK and cellular pathways of regulation. ...[more]

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