Ontology highlight
ABSTRACT:
SUBMITTER: Gaucher D
PROVIDER: S-EPMC2605227 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Gaucher Denis D Therrien René R Kettaf Nadia N Angermann Bastian R BR Boucher Geneviève G Filali-Mouhim Abdelali A Moser Janice M JM Mehta Riyaz S RS Drake Donald R DR Castro Erika E Akondy Rama R Rinfret Aline A Yassine-Diab Bader B Said Elias A EA Chouikh Younes Y Cameron Mark J MJ Clum Robert R Kelvin David D Somogyi Roland R Greller Larry D LD Balderas Robert S RS Wilkinson Peter P Pantaleo Giuseppe G Tartaglia Jim J Haddad Elias K EK Sékaly Rafick-Pierre RP
The Journal of experimental medicine 20081201 13
Correlates of immune-mediated protection to most viral and cancer vaccines are still unknown. This impedes the development of novel vaccines to incurable diseases such as HIV and cancer. In this study, we have used functional genomics and polychromatic flow cytometry to define the signature of the immune response to the yellow fever (YF) vaccine 17D (YF17D) in a cohort of 40 volunteers followed for up to 1 yr after vaccination. We show that immunization with YF17D leads to an integrated immune r ...[more]